Case Series
Year : 2024 Month : October Volume : 13 Issue : 4 Page : PS07 - PS10 Full Version

Impact of Anti-M on Grouping and Cross Matching: The Challenges Faced in Three Cases
Betsy Jonahs, R Krishnamoorthy, Ashwin, Niranj Rathan, Sampat Kumar
1. Postgraduate, Department of Transfusion Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India. 2. Professor and Head, Department of Transfusion Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India. 3. Associate Professor, Department of Transfusion Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India. 4. Assistant Professor, Department of Transfusion Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India. 5. Senior Resident, Department of Transfusion Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.
 
Correspondence Address :
Betsy Jonahs, R Krishnamoorthy, Ashwin, Niranj Rathan, Sampat Kumar,
Niranj Rathan,
82/10, Y Block, 4th street, Anna Nagar, Chennai-600040, Tamil Nadu, India.
E-mail: m1021001@sriher.edu.in; niranjrathan@sriramachandra.edu.in
 
ABSTRACT
: Anti-M, a frequently encountered antibody of the MNS blood group system, is commonly regarded as a naturally occurring saline agglutinin that can occasionally exhibit clinically significant behaviour. Particularly when reactive at 37°C or during the antiglobulin phase, it can complicate pretransfusion testing and patient management in the blood bank. Three distinct cases (2 males. 1 female) in varying clinical scenarios, ranging from surgery to acute coronary syndrome, are described. The present cases presented discrepancies in blood grouping and compatibility testing, highlighting the challenges posed by the presence of Anti-M antibodies that react at or above room temperature and during the antiglobulin phase, thus defying the usual expectations. It is imperative to provide antigen-negative red cells and those that are compatible by an Indirect Antiglobulin Test (IAT) when Anti-M is reactive at 37°C to ensure safe transfusion. Hence, there is a need to underscore the potential clinical implications in transfusion medicine, as well as the nuances of detecting, identifying, and managing the presence of Anti-M antibodies in patients requiring transfusion.
Keywords : Antibodies, Antiglobulin test, Blood transfusion, Cold agglutinins
DOI and Others : DOI: 10.7860/NJLM/2024/70035.2880 Date of Submission: Feb 19, 2024 Date of Peer Review: Apr 05, 2024 Date of Acceptance: Jun 04 ,2024 Date of Publishing: Oct 01, 2024 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was informed consent obtained from the subjects involved in the study? NA • For any images presented appropriate consent has been obtained from the subjects. NA PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Feb 20, 2024 • Manual Googling: Apr 25, 2024 • iThenticate Software: Jun 03, 2024 (13%) Etymology: Author Origin Emendations: 7
 
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