Original article / research
Year : 2023 Month : October Volume : 12 Issue : 4 Page : BO17 - BO20 Full Version

Relationship of Age and Gender with Total Serum Immunoglobulin E Levels in Adults- A Cross-sectional Study
Nitin Tangri, Neeru Bhaskar, Prabhaker Mishra, Priyanka Tangri
1. Professor, Department of Respiratory Medicine, Adesh Medical College and Hospital, Shahbad (M), Kurukshetra, Haryana, India. 2. Professor and Head, Department of Biochemistry, Adesh Medical College and Hospital, Shahbad (M), Kurukshetra, Haryana, India. 3. Additional Professor, Department of Biostatistics and Health Informatics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. 4. Professor, Department of Biochemistry, Adesh Medical College and Hospital, Shahbad (M), Kurukshetra, Haryana, India.
 
Correspondence Address :
Nitin Tangri, Neeru Bhaskar, Prabhaker Mishra, Priyanka Tangri,
Dr. Priyanka Tangri,
Professor, Department of Biochemistry, Adesh Medical College and Hospital, Shahbad (M), Kurukshetra, Haryana-136135, India.
E-mail: dr.priyankatangri@gmail.com
 
ABSTRACT
: Introduction: Immunoglobulin E (IgE) plays a crucial role in various allergic diseases. These antibodies are produced in response to allergenic environmental stimuli, and their blood levels strongly correlate with allergy manifestations. Elevated IgE levels have been considered a powerful predictor of future asthma development. While several studies have explored the association between total serum IgE levels and demographic and environmental factors, no such study has been conducted in this region of India.

Aim: To estimate total serum IgE levels and examine their association with age and gender in the adult population of Haryana, India.

Materials and Methods: A cross-sectional study was conducted in the Department of Respiratory Medicine, Adesh Medical College and Hospital, Shahabad (M), Kurukshetra, Haryana, India. The records of patients, who visited the department between September 2015 and December 2020 were screened. Data on serum total IgE levels, age, and gender were collected from 360 patients (21-80 years, both sexes) with available information. Statistical analyses were performed using Statistical Package for Social Sciences (SPSS) version 23.0 software.

Results: The mean age of the study participants was 36.80±18.30 years. Out of total 360 patients included, 198 (55%) were males and 162 (45%) were females. Male gender (odds ratio=1.68) was a significant (p<0.05) independent risk factor, while age ≤30 years (odds ratio=1.68) and age 31-50 years (odds ratio=1.15) were insignificant (p>0.05) risk factors for abnormal serum total IgE levels.

Conclusion: Significant gender variation was observed in total serum IgE levels, while age showed insignificant variation. Physicians should consider these factors when examining the relationship between serum total IgE levels, allergy markers, and airways disease.
Keywords : Antibodies, Asthma, Allergy marker, Inflammatory response
DOI and Others : DOI: 10.7860/NJLM/2023/62297.2777 Date of Submission: Dec 15, 2022 Date of Peer Review: Feb 03, 2023 Date of Acceptance: Apr 26, 2023 Date of Publishing: Oct 01, 2023 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was Ethics Committee Approval obtained for this study? Yes • Was informed consent obtained from the subjects involved in the study? No • For any images presented appropriate consent has been obtained from the subjects. No PLAGIARISM CHECKING METHOD
 
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