Original article / research
| Year :
2022 |
Month :
July
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Volume :
11 |
Issue :
3 |
Page :
MO17 - MO19 |
Full Version
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Antibiotic Sensitivity Pattern of Non Fermentative Gram Negative Bacilli in a Tertiary Care Hospital, Kakinada, Andhra Pradesh, India
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Neerajakshi Reddi, Gaddiparthi Israel
1. Assistant Professor, Department of Microbiology, Rangaraya Medical College, Kakinada, Andhra Pradesh, India.
2. Assistant Professor, Department of Microbiology, Rangaraya Medical College, Kakinada, Andhra Pradesh, India.
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Correspondence
Address :
Neerajakshi Reddi, Gaddiparthi Israel,
Dr. Neerajakshi Reddi,
Assistant Professor, Department of Microbiology, Rangaraya Medical College,
Kakinada-533001, Andhra Pradesh, India.
E-mail: drneerajakshi@gmail.com
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| | | ABSTRACT |  | : Introduction: Non Fermentative Gram Negative Bacilli (NFGNB), which are saprophytic in nature, have emerged as important pathogens. They have been associated with infections such as septicaemia, meningitis, pneumonia, urinary tract infections and surgical site infections. They exhibit resistance to beta lactams and also to other groups of antibiotics and carbapenems.
Aim: To identify and isolate NFGNB from various clinical samples and to know their antimicrobial susceptibility pattern.
Materials and Methods: The present study was a cross-sectional study done in the Department of Microbiology, Rangaraya Medical College, Kakinada, Andhra Pradesh, India, from July 2018 to August 2019. The study was done on 204 clinical samples that were inoculated on different growth media. The non fermenters were identified by conventional methods and isolates that were not identified, were subjected to automated system (MicroScan autoSCAN-4 system). The susceptibility testing was done by Kirby-Bauer disc diffusion method. Data was entered in Microsoft Excel sheet 10 and all analysis was performed by Statistical Package for the Social Sciences (SPSS) 24.0.
Results: A total of 100 NFGNB were isolated from 204 clinical samples. Pseudomonas aeruginosa (P. aeruginosa) was the most common non-fermenter (49%), followed by Acinetobacter baumannii (A. baumannii) (19%), P. fluorescens (17%), Acinetobacter lwoffii (A. lwoffii) (4%), Alcaligenes faecalis (A. faecalis) (4%), Burkholderia cepacia (B. cepacia) (3%), Pseudomonas putida (P. putida) (2%) and Stenotrophomonas maltophilia (S. maltophilia) (2%). NFGNB, showed good sensitivity to imipenem (97%), amikacin (53%), and 92% resistance to cefipime, 75%, 73%, 49%, and 48%, resistance to ceftazidime, ticarcillin, ciprofloxacin, piperacillin, respectively.
Conclusion: P. aeruginosa and A. baumannii were the common NFGNB isolated in the present study from surgical site infections, urinary tract infections, bacteraemia, and ventilator associated pneumonia. The different species of NFGNB have shown a varied sensitivity pattern. All NFGNB showed higher rate of resistance to cefipime and ceftazidime and good sensitivity to imipenem, and amikacin. |
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| Keywords
: A. baumannii, Imipenem, Nosocomial pathogens, P. aeruginosa, Resistance pattern |
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| DOI and Others
: DOI: 10.7860/NJLM/2022/53716.2648
Date of Submission: Jan 06, 2022
Date of Peer Review: Feb 02, 2022
Date of Acceptance: Apr 25, 2022
Date of Publishing: Jul 01, 2022
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
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