Original article / research
Year : 2022 Month : January Volume : 11 Issue : 1 Page : BO20 - BO23

Levels of Serum Selenium and Zinc in Critically ill Type 2 Diabetics and Normal Healthy Individuals at Tertiary Care Hospital, Surat, India
Sheetalkumari Paresh Patel, Dvss Ramavataram, N Chandrika, Hasitkumar Dalpatbhai Lad
1. Tutor, Department of Biochemistry, Surat Municipal Institute of Medical Education and Research, Surat, Gujarat, India. 2. Professor, Department of Biochemistry, Smt. B. K. Shah Medical Institute and Research Centre and Dhiraj Hospital, Vadodara, Gujarat, India. 3. Associate Professor, Department of Biochemistry, Chamarajanagar Institute of Medical Sciences, Chamarajanagar, Karnataka, India. 4. Associate Professor, Department of Biochemistry, Surat Municipal Institute of Medical Education and Research, Surat, Gujarat, India.
 
Correspondence Address :
Sheetalkumari Paresh Patel, Dvss Ramavataram, N Chandrika, Hasitkumar Dalpatbhai Lad,
Hasitkumar Dalpatbhai Lad,
A-106, Department of Biochemistry, SMIMER Medical College, Opp. New Bombay Market, Umarwada, Surat: 395010, Gujarat, India.
E-mail: hasitlad@gmail.com
 
ABSTRACT
: Introduction: Type 2 Diabetes Mellitus (T2DM), accounting for 85-90% of diabetic subjects globally, is reported to be also caused by imbalance between pro-oxidant and antioxidant factors. This very fact necessitates exploring and evaluating the possibilities of role of various antioxidant trace elements like selenium and zinc, in further understanding the pathogenesis and appropriate applicable intervention required, if any for patients suffering from diabetes mellitus. The levels of trace elements like selenium and zinc, representing antioxidant capacity, might be implicated in development of type II diabetes and vice versa.

Aim: To evaluate the levels of serum selenium and zinc in critically ill type 2 diabetic patients and comparing them with healthy individuals.

Materials and Methods: This case-control study was conducted for a period of nine months from October 2016 to June 2017. Fifty critically ill type 2 diabetic patients and 150 apparently healthy age and gender matched controls were recruited into this study. Serum selenium and zinc levels were estimated in subjects of both the groups. Mean, standard deviation, Analysis of Variance (ANOVA) test and student t-test were statistical tools used to interpret the results.

Results: Fifty critically ill T2DM patients constituted the cases and 150 age and sex matched healthy adults were in the control group. Mean Random Blood Sugar (RBS) in controls was 113.14±25.52 mg/dL while in that in cases was 246.48±98 mg/dL and the difference was significant (p-value <0.01). This study showed significant difference (p<0.01) in the level of serum selenium and zinc levels in critically ill diabetic patients compared to healthy individuals across all age groups i.e., <40, 40 to 55 and >55 years. The mean level of selenium in cases and controls were 83.8±11.97 and 103.08±67.7 µg/dL (p-value <0.01) respectively. The mean level of zinc amongst cases and controls were 40.83±21.19 and 103.08±67.7 (p-value <0.01), respectively.

Conclusion: Serum selenium and zinc levels were decreased in critically ill type 2 diabetic patients owing to the increased production of free radicals in them. Supplementation of selenium and zinc in these individuals could be beneficial and is therefore recommended.
Keywords : Antioxidant, Oxidative stress, Trace minerals, Therapeutic supplementation
DOI and Others : DOI: 10.7860/NJLM/2022/51859.2574

Date of Submission: Aug 10, 2021
Date of Peer Review: Aug 31, 2021
Date of Acceptance: Oct 20, 2021
Date of Publishing: Jan 01, 2022

AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA

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