Original article / research
| Year :
2022 |
Month :
April
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Volume :
11 |
Issue :
2 |
Page :
BO01 - BO04 |
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Clinical Epidemiology of Multidrug Resistant Tuberculosis in a Nodal Drug Resistant-TB Centre in Southern Odisha: A Cross-sectional Study
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Nalini Prava Das, Abinash Panda
1. Associate Professor, Department of Tuberculosis and Chest Diseases, MKCG Medical College, Berhampur, Odisha, India.
2. Associate Professor, Department of Pharmacology, MKCG Medical College, Berhampur, Odisha, India.
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Correspondence
Address :
Nalini Prava Das, Abinash Panda,
Dr. Abinash Panda,
Associate Professor, Department of Pharmacology, MKCG Medical College,
Berhampur, Odisha, India.
E-mail: drabinashpanda@rediffmail.com
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| | | ABSTRACT |  | : Introduction: Multidrug-Resistant Tuberculosis (MDR-TB) is a significant public health problem. The number of MDR-TB cases is very high in India and the management is inadequate due to resource constraints. The assessment of MDR-TB burden has to be reliable for programmatic management of MDR-TB under the Revised National Tuberculosis Control Program (RNTCP) of India.
Aim: To find the clinico-demographic profile and pattern of MDR-TB among the tuberculosis patients reporting to a nodal tuberculosis centre in Southern Odisha, India.
Materials and Methods: The patient record based cross-sectional study was carried out on a convenience sample of 125 sputum positive MDR-TB cases admitted to the Directly Observed Treatment Short-course (DOTS) plus centre of the Nodal Tuberculosis Centre at Berhampur, Odisha, India, during the period from April 2017 to March 2018. A predesigned case record form was used to collect data on the socio-demographic profile, addictions, co-morbidity, Human Immunodeficiency Virus (HIV) status, Bacille CalmetteGuerin (BCG) immunisation status, pattern of drug resistance, history of anti-TB treatment, presenting symptoms at admission, adverse drug reactions observed during the treatment for MDRTB. The data was analysed using GraphPad Prism trial version 7.0. Descriptive statistics were used to present the final data.
Results: Highest number of study participants (95, 76%) were within 18-45 years age group and 90 (72%) of the patients were males. Rural habitation (90, 72%), engagement in labour works (65, 52%), low socio-economic status (75, 60%) were the common socio-economic characteristics. Resistance to rifampicin was the commonest variety 101 (80.8%) and 80 (64%) were newly diagnosed cases of tuberculosis. The commonest presenting symptom was cough in 97 (77.6%) patients and gastrointestinal upset was the commonest adverse drug reaction encountered during therapy.
Conclusion: The MDR-TB affects the population in their most productive age. Rifampicin resistant TB was the predominant variety observed in the study population. The MDR-TB can be successfully treated with maximally effective and complete drug regimes |
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| Keywords
: Demography, Isoniazid resistance, Mycobacterium tuberculosis, Rifampicin resistance |
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DOI and Others
: DOI: 10.7860/NJLM/2022/53247.2591
Date of Submission: Nov 10, 2021
Date of Peer Review: Dec 14, 2021
Date of Acceptance: Jan 06, 2022
Date of Publishing: Apr 01, 2022
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? NA
• For any images presented appropriate consent has been obtained from the subjects. No
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