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| Year:
2023 |
Month:
July
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Volume:
12 |
Issue:
3 |
Page:
MO29 - MO33 |
Prevalence and Antibiogram of Pseudomonas Aeruginosa Isolated from Various Clinical Specimens: A Cross-sectional Study from a Rural Teaching Tertiary Care Hospital in Southern Haryana, India
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Correspondence
Prashant Singh, Pratibha Mane, Pooja Singla, Jyoti Sangwan,
Prashant Singh,
134, Kanishka Apartment, C&D Block Shalimar Bagh-110088, New Delhi, India.
E-mail: prashant50557@gmail.com :
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Introduction: Pseudomonas aeruginosa is an opportunistic pathogen because of its adaptive nature and a well-known cause of both community and hospital acquired infections. Varied prevalence and antimicrobial susceptibility pattern has been observed due to several reasons. Multidrug Resistant (MDR) P.aeruginosa is a global concern.
Aim: To find out the prevalence and antimicrobial susceptibility pattern of P.aeruginosa isolates obtained from various clinical samples from a rural teaching tertiary care hospital in Nalhar (Nuh), Haryana, India.
Materials and Methods: This was a one year cross-sectional study done in Department of Microbiology, SHKM GMC, Nalhar, Haryana, India from February 2019 to January 2020. On the total 6306 samples were collected and processed. The isolates were processed and identified by standard microbiological techniques. Antimicrobial Susceptibility Testing (AST) was done by Kirby-Bauer disc diffusion method as per Clinical and Laboratory Standards Institute (CLSI) guidelines. Metallo-Beta-Lactamase (MBL) detection in Pseudomonas aeruginosa was done by epsilometer-test. Bivariate analysis was done using Chi-square statistics. Statistically significant association was set with p-value <0.05.
Results: Total of 170 P.aeruginosa isolates were received,among which 100 (58.82%) isolates were from male patients and remaining 70 (41.18%) from female patients. The age of patients infected with P.aeruginosa ranges from ≤20 years to ≤60 years with the mean age 33.6 years. P.aeruginosa was isolated in 170 (2.7%) out of total 6306 samples received in the bacteriology laboratory during the study period. It was significantly observed among indoor patients, elderly (>60 years), and had undergone any invasive procedure. Antibiotic sensitivity patterns of P.aeruginosa isolates were colistin and polymixin B (98.82%), imipenem, meropenem and piperacillin-tazobactum (70%), amikacin (64.12%), gentamycin (48.82%), ciprofloxacin (54.12%) cefepime (54.71%), ceftazidime (38.24%). The most common specimen source for both MBL P.aeruginosa (PA) and non MBL PA was pus (75.61% and 53.49%). MDR was shown by (42.35%) isolates. All the MBL producers (100%) were MDR in comparison to of non MBL producers (24%).
Conclusion: This study would help to formulate the antibiotic guidelines and guide the physician in patient management which in turn has a great impact in preventing the mortality and morbidity associated with Pseudomonas aeruginosa infections.
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