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| Year:
2017 |
Month:
July
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Volume:
6 |
Issue:
3 |
Page:
PO06 - PO12 |
Expression of Ki67 as a Prognostic Marker in Invasive Breast Carcinoma
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Correspondence
Rashi Ahuja, Neena Chauhan, Sunil Saini, Meena Harsh,
Dr. Rashi Ahuja,
12, Municipal Road, Dalanwala,
Dehradun-248001, Uttarakhand, India.
E-mail: rashi.ahuja187@gmail.com :
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Introduction: Breast cancer is the most common cancer
in women of developed countries. It accounts for 16% and
22.9% of cancers and invasive cancers, respectively. About
18.2% of deaths related to cancer amongst men and women
have been attributed to breast cancer. Every year, more than
10,000 incipient breast cancer patients reckon to be diagnosed
in India.
Aim: To evaluate the role of Ki67 as a predictive biomarker in
invasive breast cancer patients and to study its correlation with
various molecular subtypes of breast cancer.
Materials and Methods: A cross-sectional and descriptive
study, of 100 cases of breast carcinoma coming to
Histopathology section in Department of Pathology, Himalayan
Institute of Medical Sciences, Swami Rama Himalayan
University, Dehradun, India, was carried out over a period of
one year, from 2013 to 2014. Patients were randomly selected
for the study.
Results: Sixty nine patients showed high proliferating index
of Ki67 (>30%), followed by 20% patients that showed
low proliferating index (=15%) and 11% patients showed
intermediate proliferating index (16-30%). Maximum
patients were of Luminal A subtype, of which 50% showed
high proliferating index. In the Luminal B subtype, 64%
patients showed high proliferating index and in the Her-2
subtype, 73.9% showed high proliferating index. Of Triple
Negative Breast Cancer (TNBC) subtype 86.3% showed high
proliferating index. Majority of patients were of IDC (n=94). Out
of these, 64(68%) patients showed high proliferating index for
Ki67 immunostaining. Out of 5 patients of ILC, 3 (60%) showed
high proliferating index for Ki67 immunostaining. One case of
mucinous carcinoma showed low proliferating index for Ki67
immunostaining.
Conclusion: High proliferating index tumours were mostly
large in size. We could not find any correlation with various
molecular subtypes of breast carcinoma. Though, not statistically
significant, we observed that TNBC were most aggressive and
showed highest rate of proliferation and Ki67 expression.
High levels of Ki67 were associated with TNBC, Her2/neu and
Luminal B while low and medium levels with Luminal A subtype.
Ki67 immunostaining
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