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| Year:
2017 |
Month:
April
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Volume:
6 |
Issue:
2 |
Page:
BO04 - BO06 |
A Comparative Assessment of Serum Malondialdehyde Level and Paraoxonase Activity in Healthy and Kwashiorkor Children
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Correspondence
Ravinder K Arora, Jyoti Diwedi, Surendra Pratap Mishra,
Dr. Surendra Pratap Mishra,
Associate Professor, Department of Biochemistry,
Institute Medical Sciences, Banaras Hindu University,
Varanasi-221005, Uttar Pradesh, India.
E-mail: drsurendram2@gmail.com :
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Introduction: Malnutrition is associated with increased oxidative stress. Increased oxidative stress can change the cellular function in many diseases including protein energy malnutrition.
Aim: To compare serum malondialdehyde level and paraoxonase activity in healthy and kwashiorkor children.
Materials and Methods: This case-control study was done to assess the serum level of Paraoxonase 1 (PON1) and Malondialdehyde (MDA) level in kwashiorkor (as cases) and healthy children (as control). Serum MDA levels and PON1 levels were measured spectrophotometrically.
Results: The level of MDA was significantly increased in kwashiorkor children (p<0.001) and PON 1 activity was significantly decreased in kwashiorkor children (p<0.001)
Conclusion: The study concluded that increased oxidative stress results in decreased antioxidant system. Hence, children suffering from malnutrition should be given antioxidant supplement so as to reduce the severity of the disease.
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