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| Year:
2015 |
Month:
July
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Volume:
4 |
Issue:
3 |
Page:
30 - 35 |
Testicular Germ Cell Tumours: A Review of Genetics, Morphology and Immunohistochemistry
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Correspondence
Kanwardeep Kaur Tiwana, Sarita Nibhoria, Ashish Yadav, Tanvi Monga, Akanksha Bajaj,
Dr. Kanwardeep Kaur Tiwana,
H.No. 75 Medical College Campus Faridkot
Punjab-151203, India.
E-mail: kanwardeepjhajj@gmail.com :
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Testicular Germ Cell Tumours (TGCTs) are rare tumours but
they are the most common solid malignancy in young males
and second leading cause of mortality. They exhibit biological
diversity making them interesting for academics. They are true
experiments of nature making their genetics very interesting.
They provide an apt model to study transformation of pluripotent
cells from totipotent germ cell. The treatment modalities are
different for TGCTs so pathologists must be very clear about the
diagnosis, as the earlier correct diagnosis has high cure rate.
This article reviews the genetics, histogenesis, morphological
details of TGCTs with stress on use of immunohistochemical
stains to differentiate tumours and various dilemmas faced by
the pathologist.
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