N J L M

 
Subscribe Via RSS
  • Home
  • About
    Salient Features Bibliographic Information Abstracting and Indexing Specialties Covered Publisher
  • Issues
    Current Issue Online Ahead of Print Archive Forthcoming issue
  • Editorial
    Editorial Statements Editorial-PeerReview Process Editorial Board Publication Ethics & Malpractice Join us
  • Authors
    Submit an Article Manuscript Instructions Manuscript Assistance Publication Charges Paid Services Early Online Publication Service
  • Reviewers
    Apply as Reviewer Reviewers Acknowledgment
  • Search
    Simple Search Advanced Search
  • Member
    Register Login
  • Contact
  • Subscription
Original article / research
Year : 2023 Month : July-September Volume : 12 Issue : 3 Page : BO17 - BO21

Spirometric Evaluation of Pulmonary Expiratory Flow Volume and Flow Rate in Patients with Clinical Hypothyroidism at a Tertiary Care Hospital, West Bengal, India: A Case-control Study

 
Correspondence Address :
Joyashree Banerjee,
Flat No. C/8, Government Housing Estate, 82-Belgachia Road , Kolkata-37, West Bengal, India.
E-mail: banerjeedrjoyashree@gmail.com
Introduction: Hypothyroidism is defined as a clinical condition caused by insufficient thyroid hormone secretion from the thyroid gland as a result of structural or functional defects in thyroid hormone production. Hypothyroidism can impair respiratory function and cause ventilation problems. Spirometry is used to assess pulmonary function in patients with thyroid disorders because low thyroid hormone levels can cause bronchial hyperactivity and obstructive pulmonary disease.

Aim: To find out the changes of spirometric parameters in clinical hypothyroid patients compared to apparently healthy individuals.

Materials and Methods: The study was a case-control study conducted in the Department of Physiology of Burdwan Medical College and Hospital on 50 cases and 50 apparently healthy subjects. Inclusion criteria were diagnosed cases of clinical hypothyroidism, Body Mass Index (BMI) under 30 kg/m2, and age between 20 to 50 years. Serum TSH and free T4 (FT4) were measured by Quantitative EIA method using RFCL-manufactured commercial “ELISCAN-TSH”-kitand“ELISCAN-Ft4”-kit. Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 second (FEV1), FEV1/FVC, Forced Expiratory Flow (FEF) of 25-75%, and Peak Expiratory Flow Rate (PEFR) parameters of pulmonary function test were tested by RMS Helios 401 Spirometer. Pearson’s two-tailed correlation study and student independent-test were done for analysis.

Results: The present study showed that spirometric parameters FEV1, FVC, FEV1/FVC, PEFR and FEF25%-75% were significantly decreased in clinical hypothyroidism compared to control. Mean values of parameters of FEV1, FVC, FEV1/FVC, PEFR and FEF25%-75% in clinical hypothyroid cases were 85.30%, 92.42%, 90.70%, 74.86%, and 75.63%, respectively which were significantly (p<0.001) decreased compared to that of healthy individuals.

Conclusion: This study concluded that clinical hypothyroidism causes significant changes in respiratory function. Thus, a proper knowledge in respect to this infection would help in management of these patients in time.
 
[ FULL TEXT ]   |   [ ]
 
  • Article Utilities

    • Readers Comments (0)
    • Article in PDF
    • Citation Manager
    • Article Statistics
    • Link to PUBMED
    • Print this Article
    • Send to a Friend
  • Go To Issues

    • Current Issue
    • Past Issues
  • Search Articles

    • Simple Search
    • Advance Search
  • Authors Facilities

    • Extensive Author Support
    • Submit Manuscript
    • ONLINE First Facility
    • NJLM Pre Publishing
  • Quick Links

    • REVIEWER
    • ACCESS STATISTICS
  • Users

    • Register
    • Log in
  • Pages

    • About
    • Issues
    • Editorials
    • Authors
    • Reviewers
    • Search
    • Contacts
  • Issues Archives

  • Affiliated Websites

    • JCDR Prepublishing
    • Neonatal Database Home
    • JCDR Neonatal Database download center