Original article / research
Year : 2025 Month : October Volume : 14 Issue : 4 Page : BO05 - BO08 Full Version

Association between Mid-trimester Maternal Triglyceride Levels and Subsequent Development of Preeclampsia: A Prospective Cohort Study
Alisha Singh, Madhumita De, Rajarshi Ray, Sangeeta Dubey, Sradha Kedia, Ishita Sinha, Abhijit Rakshit
1. Assistant Professor, Department of Obstetrics and Gynaecology, The Oxford Medical College Hospital and Research Centre, Bengaluru, Karnataka, India. 2. Associate Professor, Department of Physiology, R.G. Kar Medical College, Kolkata, West Bengal, India. 3. Assistant Professor, Department of Physiology, R.G. Kar Medical College, Kolkata, West Bengal, India. 4. Resident Medical Officer Cum Clinical Tutor, Department of Obstetrics and Gynaecology, R.G. Kar Medical College, Kolkata, West Bengal, India. 5. Senior Resident, Department of Obstetrics and Gynaecology, R.G. Kar Medical College, Kolkata, West Bengal, India. 6. Assistant Professor, Department of Obstetrics and Gynaecology, Nowrosjee Wadia Maternity Hospital, Mumbai, Maharashtra, India. 7. Professor, Department of Obstetrics and Gynaecology, R.G. Kar Medical College, Kolkata, West Bengal, India.
 
Correspondence Address :
Abhijit Rakshit,
UTL010406, Utalika the Condoville, 405 Barakhola, Mukundapur,
Kolkata-700099, West Bengal, India.
E-mail: drabhijitr81@gmail.com
 
ABSTRACT
: Introduction: Hyperlipidaemia, specifically hypertriglyceridaemia, is a well-known risk factor for metabolic syndrome and cardiovascular atherosclerosis. Serum triglyceride levels are significantly elevated in women with Hypertensive Disorders of Pregnancy (HDP), and such elevations are consistent across the first, second, and third trimesters of pregnancy. Therefore, triglyceride levels in the early mid-trimester can act as predictors for the development of preeclampsia.

Aim: To determine whether serum triglyceride levels measured during the early mid-trimester of pregnancy can serve as a predictive biomarker for the development of preeclampsia.

Materials and Methods: A hospital-based prospective cohort study was conducted in the maternity unit of the Department of Obstetrics and Gynaecology at R.G. Kar Medical College and Hospital, Kolkata, West Bengal, India from February 2020 to July 2021. Serum triglyceride levels were measured, and participants were divided into two groups of 75 each. Group 1 had normal serum triglyceride levels, while Group 2 had high triglyceride levels. The Adult Treatment Panel (ATP) III classification of serum triglycerides was used, with values >200 mg/dL taken as the cut-off level. Patients were followed up until delivery, and the incidence of preeclampsia was recorded in both groups. The Chi-square test was employed to compare categorical variables.

Results: The mean age of the study participants in Group 1 and Group 2 was 25.8±3.86 and 26.6±4.29 years, respectively. Group 1 (normal triglyceride levels) had seven cases of preeclampsia, whereas Group 2 (hypertriglyceridaemia) had 17 cases. Overall, the study demonstrated that high serum triglyceride levels in the antenatal period were statistically significant in predicting the occurrence of preeclampsia during pregnancy (p-value=0.02).

Conclusion: Higher serum triglyceride levels were found to be associated with an increased incidence of preeclampsia.
Keywords : Atherosclerosis, Hypertriglyceridaemia, Predictor, Pregnancy
DOI and Others : DOI: 10.7860/NJLM/2025/79677.2939 Date of Submission: Apr 01, 2025 Date of Peer Review: Jun 11, 2025 Date of Acceptance: Jul 30, 2025 Date of Publishing: Oct 01, 2025 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was Ethics Committee Approval obtained for this study? Yes • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. NA PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Jun 10, 2025 • Manual Googling: Jul 22, 2025 • iThenticate Software: Jul 29, 2025 (15%) ETYMOLOGY: Author Origin EMENDATIONS: 6
 
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