Original article / research
Role of Oxidative Stress on Malarial Anaemia: Significance of Oxidative Stress Index in Patients with Malarial Infection
Dr. DS Jagannadha Phaneendra,
ESIC Medical College, Sanathnagar, Hyderabad-500038, Telangana, India.
Introduction: An alteration of oxidant and antioxidant levels is thought to be involved in the pathogenesis of malaria. Limited data is found on association between oxidant and antioxidant status and significance of oxidative stress index in patients with malarial infection and anaemia in south Indian population.
Aim: To measure the levels of oxidants and antioxidants and oxidative stress index in patients with malaria and their association with anaemia.
Materials and Methods: The present study was a case-control study in which a total of 50 subjects of malaria aged 20-45 years were included as cases based on inclusion criteria and exclusion criteria. Control group comprised of 50 healthy age and gender matched subjects. Haemoglobin (Hb), serum Malondialdehyde (MDA), Superoxide Dismutase (SOD), Total Antioxidant Capacity (TAC) was estimated in both the groups by standard methods using Ultraviolet Spectrophotometer.
Results: MDA was significantly elevated in cases as compared to controls (p<0.0001). SOD, Ferric Reducing Ability of Plasma (FRAP), Hb were significantly lower in cases as compared to controls (p<0.0001, p<0.0001, p<0.0001 respectively). In the present study it was found that there was a significant correlation between Hb and oxidative stress index (MDA/FRAP) in patients with malaria.
Conclusion: The present study concluded that oxidative stress might be a cause of malarial anaemia. Alterations in oxidant and antioxidant levels might have a role in pathogenesis of malaria. As compared to individual markers, oxidative stress index was found to be significantly associated with malarial anaemia denoting its role as a better marker in these patients. Antimalarial therapy targeting the above factors might decrease the pathogenesis, morbidity and mortality in patients with malaria.
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