N J L M

 
Subscribe Via RSS
  • Home
  • About
    Salient Features Bibliographic Information Abstracting and Indexing Specialties Covered Publisher
  • Issues
    Current Issue Online Ahead of Print Archive Forthcoming issue
  • Editorial
    Editorial Statements Editorial-PeerReview Process Editorial Board Publication Ethics & Malpractice Join us
  • Authors
    Submit an Article Manuscript Instructions Manuscript Assistance Publication Charges Paid Services Early Online Publication Service
  • Reviewers
    Apply as Reviewer Reviewers Acknowledgment
  • Search
    Simple Search Advanced Search
  • Member
    Register Login
  • Contact
  • Subscription
Original article / research
Year : 2020 Month : October-December Volume : 9 Issue : 4 Page : PO20 - PO25

Cholecystectomy Specimens: Histopathological Assessment of 923 Cases with Emphasis on Unpredictable Diagnosis

 
Correspondence Address :
Poonam Arora,
5, Ambika Nagar, Savitri Vatika Road, Hiran Magri, Sector 4, Udaipur, Rajasthan, India.
E-mail: poonam86dr@gmail.com
Introduction: Cholecystectomy specimens show wide clinicopathological spectrum varying from common non-neoplastic diseases to rare neoplastic lesions. Often, Gall bladder disease is diagnosed on the basis of clinical and radiological findings, but histopathology remains the gold standard for the final diagnosis. Intraoperative frozen section followed by histopathological examination of the cholecystectomy specimen which aid in the diagnosis of the incidental carcinomas.

Aim: To analyse the histomorphological findings of cholecystectomy specimens with emphasis on unpredictable diagnosis.

Materials and Methods: The retrospective study was conducted from January 2017 to May 2020 in the Department of Pathology at a tertiary care centre in Udaipur. A total of 923 cholecystectomy specimens were evaluated for Histopathological examination. Intraoperative Frozen sections were also studied in clinically suspicious cases. Results were analysed using SPSS version 21. Quantitative variables were expressed as mean±Standard Deviation (SD), whereas qualitative variables were expressed as absolute and relative frequencies.

Results: Cholecystectomy specimens were examined over a wide age range of 22 years to 88 years of age. The male to female ratio was found to be 1:2.27 in non-neoplastic cases and 1:6.28 in neoplastic cases. On microscopy, the most common histopathological lesion encountered was Chronic cholecystitis (766 cases, 82.99%). Other non-neoplastic pathology included acute cholecystitis (36 cases, 3.9%), cholesterolosis (20 cases, 2.16%), gangrenous cholecystitis (15 cases, 1.6%), adenomyomatous hyperplasia (9 cases, 0.97%), Empyema (6 cases, 0.65%), Mucocele (5 cases, 0.54%), Xanthogranulomatous cholecystitis (3 cases, 0.32%), and others (12 cases, 1.30%). Neoplastic lesions included Carcinoma (41cases, 4.44%), Biliary Intraepithelial Neoplasia (BilIN- 04 cases, 0.43%) and Intracholecystic papillary neoplasm (ICPN- 06 cases, 0.65%). In eight (0.87%) cases we found unexpected histopathological diagnosis not correlating with the clinical findings and two cases showed the presence of incidental Gall Bladder (GB) carcinoma.

Conclusion: Histopathological examination of cholecystectomy specimens assist in confirming the preoperative diagnosis and proper sampling from any thick wall or suspicious area helps to rule out any incidental findings of dysplasia or malignancy. Frozen sections should be carried out in suspicious cases that further aid in the proper management of the patient.
 
[ FULL TEXT ]   |   [ ]
 
  • Article Utilities

    • Readers Comments (0)
    • Article in PDF
    • Citation Manager
    • Article Statistics
    • Link to PUBMED
    • Print this Article
    • Send to a Friend
  • Go To Issues

    • Current Issue
    • Past Issues
  • Search Articles

    • Simple Search
    • Advance Search
  • Authors Facilities

    • Extensive Author Support
    • Submit Manuscript
    • ONLINE First Facility
    • NJLM Pre Publishing
  • Quick Links

    • REVIEWER
    • ACCESS STATISTICS
  • Users

    • Register
    • Log in
  • Pages

    • About
    • Issues
    • Editorials
    • Authors
    • Reviewers
    • Search
    • Contacts
  • Issues Archives

  • Affiliated Websites

    • JCDR Prepublishing
    • Neonatal Database Home
    • JCDR Neonatal Database download center