Original article / research
The Pathogenic and Developmental Biomarker: High Sensitivity C-Reactive Protein in Early Diagnosis of Diabetic Nephropathy
Dr. Thivyah Prabha,
No 4, Doctors Quarters, Eastpoint Medical College, Bidrahalli, Bengaluru, Karnataka, India.
Introduction: Type 2 Diabetes Mellitus (T2DM) is one of the chronic metabolic conditions leading to various complications and most commonly Diabetic Nephropathy (DN). DN imposes a major and unrecognised burden to the whole world in the management of health system and economy. High sensitivity C-Reactive Protein (hs-CRP), being an inflammatory marker, plays a pathogenic role in DN and found to be increased in diabetes patients.
Aim: To determine an earlier pathogenic marker for DN among T2DM patients.
Materials and Methods: This cross-sectional study was conducted among 92 clinically diagnosed T2DM patients. Written informed consent was obtained. Blood samples were collected and analysed for Fasting Blood Sugar (FBS), hs-CRP. Spot urine microalbumin creatinine ratio was estimated by immunoturbidimetry and Jaffe’s method, respectively. Data was statistically analysed using student t-test and correlation between analytes was analysed using Pearson correlation.
Results: Mean serum hs-CRP value of diabetic subjects with microalbuminuria was 6.9±3.2 mg/L and diabetic subjects without microalbuminuria was 1.4±0.68 mg/L. There was a positive correlation between hs-CRP and Urine Albumin Creatinine Ratio (UACR) (r=0.47; p=0.02). There was also a positive correlation between hs-CRP and FBS levels and hs-CRP and duration of type 2 diabetes mellitus. hs-CRP and UACR were elevated among type 2 diabetic patients. There was a positive correlation between hs CRP and FBS and duration of diabetes mellitus.
Conclusion: As hyperglycaemia plays a critical pathogenic role in type 2 diabetes through the inflammatory pathway, hs CRP may be suggested as a developmental biomarker of DN among T2DM patients in association with UACR.
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