N J L M

 
Subscribe Via RSS
  • Home
  • About
    Salient Features Bibliographic Information Abstracting and Indexing Specialties Covered Publisher
  • Issues
    Current Issue Online Ahead of Print Archive Forthcoming issue
  • Editorial
    Editorial Statements Editorial-PeerReview Process Editorial Board Publication Ethics & Malpractice Join us
  • Authors
    Submit an Article Manuscript Instructions Manuscript Assistance Publication Charges Paid Services Early Online Publication Service
  • Reviewers
    Apply as Reviewer Reviewers Acknowledgment
  • Search
    Simple Search Advanced Search
  • Member
    Register Login
  • Contact
  • Subscription
Original article / research
Year : 2020 Month : October-December Volume : 9 Issue : 4 Page : BO32 - BO35

The Pathogenic and Developmental Biomarker: High Sensitivity C-Reactive Protein in Early Diagnosis of Diabetic Nephropathy

 
Correspondence Address :
Dr. Thivyah Prabha,
No 4, Doctors Quarters, Eastpoint Medical College, Bidrahalli, Bengaluru, Karnataka, India.
E-mail: satjeevas@gmail.com
Introduction: Type 2 Diabetes Mellitus (T2DM) is one of the chronic metabolic conditions leading to various complications and most commonly Diabetic Nephropathy (DN). DN imposes a major and unrecognised burden to the whole world in the management of health system and economy. High sensitivity C-Reactive Protein (hs-CRP), being an inflammatory marker, plays a pathogenic role in DN and found to be increased in diabetes patients.

Aim: To determine an earlier pathogenic marker for DN among T2DM patients.

Materials and Methods: This cross-sectional study was conducted among 92 clinically diagnosed T2DM patients. Written informed consent was obtained. Blood samples were collected and analysed for Fasting Blood Sugar (FBS), hs-CRP. Spot urine microalbumin creatinine ratio was estimated by immunoturbidimetry and Jaffe’s method, respectively. Data was statistically analysed using student t-test and correlation between analytes was analysed using Pearson correlation.

Results: Mean serum hs-CRP value of diabetic subjects with microalbuminuria was 6.9±3.2 mg/L and diabetic subjects without microalbuminuria was 1.4±0.68 mg/L. There was a positive correlation between hs-CRP and Urine Albumin Creatinine Ratio (UACR) (r=0.47; p=0.02). There was also a positive correlation between hs-CRP and FBS levels and hs-CRP and duration of type 2 diabetes mellitus. The hs-CRP and UACR were elevated among type 2 diabetic patients. There was a positive correlation between hs-CRP and FBS and duration of diabetes mellitus.

Conclusion: As hyperglycaemia plays a critical pathogenic role in type 2 diabetes through the inflammatory pathway, hs-CRP may be suggested as a developmental biomarker of DN among T2DM patients in association with UACR.
 
[ FULL TEXT ]   |   [ ]
 
  • Article Utilities

    • Readers Comments (0)
    • Article in PDF
    • Citation Manager
    • Article Statistics
    • Link to PUBMED
    • Print this Article
    • Send to a Friend
  • Go To Issues

    • Current Issue
    • Past Issues
  • Search Articles

    • Simple Search
    • Advance Search
  • Authors Facilities

    • Extensive Author Support
    • Submit Manuscript
    • ONLINE First Facility
    • NJLM Pre Publishing
  • Quick Links

    • REVIEWER
    • ACCESS STATISTICS
  • Users

    • Register
    • Log in
  • Pages

    • About
    • Issues
    • Editorials
    • Authors
    • Reviewers
    • Search
    • Contacts
  • Issues Archives

  • Affiliated Websites

    • JCDR Prepublishing
    • Neonatal Database Home
    • JCDR Neonatal Database download center