Original article / research
Adenosine Deaminase- Relation with Diabetes and its Complication
Dr. Mohd Iqbal Dar,
Room No. 04, Sr Hostal, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
Introduction: Adenosine Deaminase (ADA), a purine metabolic enzyme is suggested to contribute significantly to the modulation of bioactivity of insulin but its relation with diabetes is not yet fully understood.
Aim: To assess the relation of ADA with diabetes and its complications.
Materials and Methods: This study included a total of 100 diabetic patients and 100 well matched healthy non-diabetic as control subjects. Serum ADA levels of patients with Diabetes Mellitus (DM) as diagnosed by current American Diabetic Association (ADA) criteria were compared with well-matched healthy non-diabetic patients, further ADA levels were compared with micro and macrovascular complications of diabetes. The recorded data was exported to Statistical Package for the Social Sciences (SPSS) version 23.0 after being compiled in Microsoft excel.
Results: The mean age of diabetic patients was 57.7±9.49 and 54.9±11.29 years for controls. Significant difference in ADA in diabetic and non-diabetics with mean ADA of 38.7±16.02 and 28.9±6.39 IU/L respectively with a p-value of <0.001 was noted. In the study group, the duration of diabetes was ≥ 10 years in 51%. Microvascular complication like retinopathy was seen in 65%, nephropathy in 31% and neuropathy in 52% cases. Macrovascular complications like Peripheral Vascular Disease (PVD) in 5%, Coronary Artery Disease (CAD) in 11% and Cerebrovascular Disease (CVD) in 9% cases. HbA1c <7% was seen in 8%, 7-10 in 44% and >10 in 48% cases. Significant correlation was observed between serum ADA and microvascular complication and duration of diabetes.
Conclusion: Serum ADA can be an addition marker of diabetes and has significant correlation with its various complications.
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