Original article / research
Role of Hepcidin in causing Anaemia of Chronic Kidney Disease: A Potential Early Biomarker
Dr. Anu C John,
Believers Church Medical College Hospital, Thiruvalla, Kerala, India.
Intrduction: Hepcidin appears to be an emerging biomarker for anaemia in kidney damage in Chronic Kidney Disease (CKD).
Aim: To evaluate serum hepcidin level for its potential role in anaemia of CKD.
Materials and Methods: A cross-sectional study was done in 60 subjects. Out of 60 subjects, 40 were patients (without type II error) suffering with CKD admitted in Department of Nephrology, in a Tertiary Care Hospital, Kerala, India between January 2012 to June 2013 and 20 were healthy subjects assigned as controls. Blood sample (10 ml) was collected from each patient before the initiation of dialysis, assayed for serum hepcidin, serum iron, Total Iron Binding Capacity (TIBC) and Serum ferritin for comparison. Statistical Package for the Social Sciences (SPSS) software version 19 was used. A p-value with < 0.05 was considered statistically significant.
Results: Mean age of patients was 56.72 years and majority were males 33 (82.5%). Mean duration of years was 4.08 years ( (Standard Deviation (SD) 1.95 years). Mean duration of haemodialysis twice a week was 2.12 years (SD 1.02 years). In this study, 23 (57.5%) patients were on recombinant human Erythropoietin (rhEpo) with good response, 10 (25%) without response and 7 (17.5%) were not on rhEpo. Comparison of serum hepcidin, Haemoglobin (Hb), serum iron, TIBC, serum ferritin in these CKD patients showed significant correlation with p-value <0.05.
Conclusion: In this study, serum hepcidin reflected iron status of CKD patients indicating a potential marker that can be assayed to predict anaemia related to early renal injury.
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