Original article / research
Utilisation of Fresh Frozen Plasma in a Tertiary Care Hospital
Dr. Ramya Chitturi,
Department of Pathology, NRI Medical College, Chinakakani-522503, Guntur, Andhra Pradesh, India.
Introduction: Fresh Frozen Plasma (FFP) is mainly used in the treatment of abnormal coagulation profile, the reversal of warfarin effect and trauma emergencies. Inappropriate FFP usage can cause adverse effects like excess volume replacement, anaphylaxis and Transfusion-Based Lung Injury (TRALI) in patients.
Aim: To focus on indications, appropriate and inappropriate usage of FFP in a tertiary care hospital.
Materials and Methods: This was a retrospective descriptional study of FFP’s issued to the patients admitted to NRI General Hospital, Chinakakani, Andhra Pradesh, India, during the period from June 2017 to June 2019. All requisition forms for the issue of FFP, other blood components were collected and analysed from the blood bank. Following parameters were taken into consideration like age, the gender of the patient, blood group, clinical diagnosis, clinical indication, the speciality of requesting clinician, other blood components and number of FFP’s transfused. Statistical data were expressed as frequencies and percentages.
Results: A total of 3644 FFP’s were issued to 1904 patients, out of which 994 patients were males, and 910 patients were females.The highest number of FFP’s were supplied to patients with active bleeding and least to patients undergoing therapeutic plasma exchange. The highest number of FFP’s were issued to the Medicine department, followed by the General surgery department and 8.92% of FFP’s were supplied to patients with Deranged Coagulation Profile (DCP), 85.93% to bleeding patients, 0.78% to patients with Disseminated Intravascular Coagulation (DIC) and 0.44% to patients undergoing therapeutic plasma exchange.
Conclusion: FFP transfusion is beneficial to patients with high pre-transfusion International Normalised Ratio (INR) value in comparison to patients with low pre-transfusion INR values. More clinical interventions, a proper compilation of requisition forms, maintenance of records, regular audit by hospital transfusion committee, formulation of guidelines regarding usage of FFP and regular academic meets are needed to improve the appropriate usage of FFP’s and to minimise their inappropriate usage.
|[ FULL TEXT ] | [ ]|