Original article / research
Clinical Utility of Serum Cystatin C in Comparison with Serum Creatinine, Urea and Uric Acid in Patients with Chronic Kidney Disease
Dr. Anu C John,
Believers Church Medical College Hospital, St. Thomas Nagar Kuttapuzha,Thiruvalla-689103, Kerala, India
Introduction: Estimation of serum creatinine is the gold standard to diagnose Chronic Kidney Disease (CKD) and estimation of cystatin C could also be an important biomarker for the same.
Aim: To assess the correlation between serum cystatin C and conventional serum markers like creatinine, urea and uric acid in CKD.
Materials and Methods: A cross-sectional study was done between January 2012 to June 2013 in a tertiary care hospital which involved 40 patients with CKD and 20 healthy controls. Blood sample (10 mL) was collected from each patient before the initiation of dialysis and used for assay of serum cystatin C, serum creatinine, urea and uric acid. Serum cystatin C was analysed by using Diagnostic kit (SensIT) using latex enhanced immunoturbidimetry method. Serum creatinine, urea and uric acid were estimated by enzymatic assay kits. The data obtained were statistically analysed using Statistical Package for the Social Sciences (SPSS) software version 19. Descriptive statistics and Pearson correlation for these markers were determined. A p-value <0.05 was considered to be statistically significant.
Results: Majority of the patients were in the age group 55-65 years (57.5%). Majority (82.5%) of the patients were males. The age of patients showed significant positive correlation with serum cystatin C and serum creatinine with p-value<0.001. Mean duration of CKD in patients was 4.08 years with a standard deviation of 1.95 years. All the 40 patients were undergoing haemodialysis twice a week and for a mean duration of 2.12 years with a standard deviation of 1.02 years. Out of the 40 patients 50% were both diabetic and hypertensive. Comparison of serum cystatin C with serum creatinine, serum urea, and serum uric acid using Pearson correlation showed significant positive correlation with p-value <0.05.
Conclusion: This study shows that serum cystatin C can be used as a reliable marker in CKD to assess declining renal function like established markers.
|[ FULL TEXT ] | [ ]|