Original article / research
Relationship between Dyslipidemia and Glycemic Status in Type-2 Diabetes Mellitus
Dharmik Savjibhai Patel,
Department of Biochemistry, Karamsad, Gujarat, India.
Introduction: India has among the largest number of diabetic subjects in the world. Dyslipidemia is a lipoprotein metabolic abnormality leading to a persistent increase in the plasmatic concentration of cholesterol and triglycerides. Studies found that increased triglyceride levels and decreased HDL cholesterol levels predicted Coronary Heart Disease (CHD). HDL may be the most consistent predictor of CHD in type 2 diabetes subjects, followed by triglyceride and total cholesterol.
Aim: To assess the link between HDL/LDL ratio and diabetic status of patients and to compare HbA1c and FBS with HDL/ LDL ratio.
Materials and Methods: This was a retrospective crosssectional study done over a period of 1 year; in the clinical biochemistry department of a tertiary care rural centre. Before starting the study, the protocol was prepared and presented to Institutional Human Research Ethics Committee which was subsequently approved. The data for 101 diabetic patients and 106 non-diabetics were considered, who attended the hospital for their routine health check-up. The following were noted from the online data centre and filled into a proforma-FBS, PP2BS, HbA1c, HDL, LDL, Tc/HDL, HDL/LDL. p-value of less than 0.05 was considered statistically significant.
Results: There was significant increase in the levels of FBS and HbA1c in diabetic group compared to the control group. The level of HDL gradually decreased, the level of LDL increased,while the HDL: LDL ratio significantly was less in the diabetic group.
Conclusion: It can be concluded that diabetes mellitus type 2 is strongly associated with lower level of high density lipoprotein and higher level of low density lipoprotein cholesterol due to which there is alteration in the HDL/LDL ratio.
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