Original article / research
Differentiating between Dengue Fever from Other Febrile Illnesses Using Haematological Parameters
Dr. Priyanka P,
Assistant Professor, Department of Pathology, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India.
Introduction: Dengue fever is the most common arthropod borne disease and major public health concerns in India. The clinical presentation of this disease is difficult to distinguish from other febrile illnesses like malaria and typhus fever. Correlation of haematological parameters helps to differentiate these diseases in early stage.
Aim: The present study aimed to identify the haematological features useful for discriminating dengue from other febrile illnesses and to evaluate the accuracy of these haematological parameters.
Materials and Methods: A retrospective study was done to differentiate between dengue and other febrile illnesses between January 2017 to July 2017 at Sri Dharmasthala Manjunatheshwara College of Medical Sciences and Hospital, Dharwad Karnataka. Data regarding haematological parameters were collected in 170 cases classified as dengue (D) and 170 cases classified as non dengue (ND) based on laboratory tests.
Results: The following parameters were significantly lower in patients with DF as compared to non dengue patients (p-value less than 0.05); WBC, Platelets, Neutrophils, Eosinophils. The following parameters were significantly higher in patients with DF as compared to non dengue cases (p<0.05): Haemoglobin, PCV, RBC count, Lymphocytes, Monocytes. Multiple logistic regression model used in this study showed two haematological predictors with positive association to confirm dengue: WBC count <4000/cumm and platelet count <1 lakh/cumm (likely to be present in dengue cases).
Conclusion: The study helps to differentiate dengue from other febrile illnesses at an early stage and avoids a large number of other investigation to diagnose dengue from other febrile illness.
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