Diagnostic Conundrum in a Case of Solid Papillary Renal Cell Carcinoma
Dr. Aruna Chhikara,
Senior Resident, Department of Pathology,
Lady Hardinge Medical College,
New Delhi-110001, India.
|Papillary Renal Cell Carcinoma (RCC) is the second most common carcinoma arising from the renal tubular epithelium. It comprises 10-15% of cases in surgical series. The solid variant of papillary RCC includes only those RCCs that lack true papillae but contain the characteristic immunohistochemical and genetic features of papillary RCC. Here, we present the clinical, histopathologic and immunohistochemical findings of a rare case report of solid variant of papillary RCC. A 45 years old female presented with left abdominal mass. Histopathological sections showed tumour cells arranged in tubules, trabeculae and cords with occasional interspersed long branching and angulated channels with pointed ends. Even extensive sampling of the tumour failed to reveal any papille. The differential diagnosis included solid papillary RCC (s-PRCC), Metanephric Adenoma (MA) and Collecting Duct Carcinoma (CDC). Histologically, these tumours may show overlapping features. The use of IHC markers panel comprising of CK7, EMA, Vimentin, AMACAR and WT1 can help to reach at a diagnosis.|
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