Original article / research
Platelet Indicies in Pre-eclampsia and Eclampsia
Dr. Deepak Donthi,
No.54, 7th Cross, 2nd main, AECS layout,
Geddalahalli, Sanjaynagar, Bengaluru-560094,
Introduction: Activation of platelets due to defective placental trophoblastic invasion in the pathophysiology of pre-eclampsia and eclampsia is known. The changes in the platelet parameters and its relevance are discussed in this article.
Aim: To compare the changes of platelet parameters in patients diagnosed with pre-eclampsia and eclampsia versus the control group of pregnant women.
Materials and Methods: A random selection of 50 normal pregnant controls and 50 patients with pre-eclampsia or eclampsia were included in the study. The platelet indices that include platelet count, Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) of both the controls and cases were documented and compared using statistical analysis.
Results: The PDW is greater in the cases than controls and shows that there was a statistically significant difference between the values of the cases versus the controls. MPV was mildly increased and platelet count mildly decreased in cases versus controls. Platelet count and MPV did not show a statistical significant difference between the cases and controls.
Conclusion: The significant difference in the PDW and the increase in MPV can contribute to the pathophysiology of pre-eclampsia and eclampsia. The changes in these parameters can provide a cue towards early diagnosis or potential worsening of pre-eclampsia and eclampsia status. However, platelet count alone is not always a potential indicator in detecting pre-eclampsia and eclampsia. Assessing the PDW can also be beneficial as an indicator of pre-eclampsia and eclampsia
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