Original article / research
Hypertension and Dyslipidemia in Type 2 Diabetes Mellitus patients of Guntur and Krishna districts in Andhra Pradesh, India
Dr. Siva Prabodh
Associate Professor, Department Of Biochemistry, Nri Medical College, Chinakakani, Guntur District, Andhra Pradesh, India, Pin Code: 522503.
Introduction: Hypertension (HTN) and Dyslipidemia (DL) when coexist with Diabetes Mellitus(DM), there is an increase in the risk of cardiovascular complications and also contributes to morbidity and mortality. Aim of our study is to find out the percentage of i)dyslipidemics among diabetics and correlation of the lipid profile status with the glycemic control ii) hypertensives among diabetics and correlation of blood pressure with glycemic control.
Methods: 100 patients with Type- 2 DM with 10–15 years of duration, aged between 45- 65 years attending the General Medicine OP in NRI General Hospital, Chinakakani from September to November, 2010 were included in the study. In each patient HbA1C, Total cholesterol, Triglycerides, HDL were estimated. Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) were measured. The results were statistically analyzed by Z-test, p-test and Pearsons correlation tests.
Results: Among 100 Type - 2 DM patients, only 21% were under good glycaemic control, 61% cases had dyslipidemia with higher Total Cholesterol (204± 40.24), higher Triglycerides (166.26± 58.68) and lower HDL-C (39.56±9.09) mg/dl,where p- value 0.001 which is highly significant. HbA1C is having a strong positive correlation with Total Cholesterol and Triglycerides where as a strong negative correlation with HDL which is highly significant. 53% cases had hypertension with SBP (126.2±13.28) and DBP (82.87±7.66)mmHg and the p- value is < 0.0001 which is highly significant. HbA1C is having weak positive correlation with SBP and DBP which is not significant.
Conclusion: Co-morbidity with HTN and DL is found to be high in the patients with Type-2 DM especially among those with poor glycaemic control. The strong association of these suggest that these patients may be at a higher risk of developing cardiovascular diseases. Further studies need to be done with regular patient follow up to find out the percentage of patients developing cardiovascular complications.
|[ FULL TEXT ] | [ ]|